Telenzepine dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1122
Potent, selective M1 antagonist
Product Description
Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.Product Specifications
Molecular Weight
443.39
Formula
C19H22N4O2S.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
CAS Number
147416-96-4
PubChem ID
6419995
InChI Key
JTQJFSQQHGPLOX-UHFFFAOYSA-N
SMILES
Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.34 | 100 |
Preparing Stock Solutions
for Telenzepine dihydrochloride
The following data is based on the product molecular weight 443.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Eltze Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 1985 PMID: 4029260
- Galvan Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 1989 PMID: 2776837
- Christofi Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 1991 PMID: 1868879
Product Specific Notices for Telenzepine dihydrochloride
For research use only
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