Telenzepine dihydrochloride

Name: Telenzepine dihydrochloride
Brand: Tocris Bioscience
SKU: 1122
Price: 88 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1122

Citations (1)

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Key Product Details

Description:	Potent, selective M₁ antagonist
Chemical Name:	4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	443.39

View Full Technical Details for Telenzepine dihydrochloride

Biological Activity for Telenzepine dihydrochloride

Telenzepine dihydrochloride is a selective high affinity muscarinic M₁ receptor antagonist (K_i = 0.94 nM). Inhibits gastric acid secretion.

Technical Data for Telenzepine dihydrochloride

M. Wt	443.39
Formula	C₁₉H₂₂N₄O₂S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	147416-96-4
PubChem ID	6419995
InChi Key	JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles	Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Telenzepine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.34	100

Preparing Stock Solutions for Telenzepine dihydrochloride

The following data is based on the product molecular weight 443.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for Telenzepine dihydrochloride

References are publications that support the biological activity of the product.

Christofi Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 1991 PMID: 1868879
Galvan Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 1989 PMID: 2776837
Eltze Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 1985 PMID: 4029260

Citations for Telenzepine dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Telenzepine dihydrochloride include:

Pediani et al. (2016) Dynamic regulation of quaternary organization of the M₁ muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem.. 291:13132
PMID: 27080256

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Product Documents for Telenzepine dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.