TCN 201

Tocris Bioscience, part of Bio-Techne | Catalog # 4154

GluN1/GluN2A-selective NMDA antagonist
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Key Product Details

Description

GluN1/GluN2A-selective NMDA antagonist

View all NMDA Receptor Antagonists »

Product Description

TCN 201 is a NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca2+ assays).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications

Molecular Weight

461.89

Formula

C21H17ClFN3O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

CAS Number

852918-02-6

PubChem ID

4787937

InChI Key

FYIBXBFDXNPBSF-UHFFFAOYSA-N

SMILES

ClC1=C(F)C=CC(S(NCC2=CC=C(C(NNC(C3=CC=CC=C3)=O)=O)C=C2)(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.19 100

Preparing Stock Solutions for TCN 201

The following data is based on the product molecular weight 461.89

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.65 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for TCN 201

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCN 201

For research use only

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