TCB-2

Name: TCB-2
Brand: Tocris Bioscience
SKU: 2592
Rating: 5 (1 reviews)

Catalog # 2592 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (9)

COA / SDS

High affinity and potent 5-HT2A agonist

Key Product Details

Description:	High affinity and potent 5-HT_2A agonist
Chemical Name:	(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	353.05

View Full Technical Details for TCB-2

Technical Data
Citations (9) / Reviews (1)

Biological Activity for TCB-2

TCB-2 is a high affinity 5-HT_2A receptor agonist (K_i values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP₃ accumulation in NIH3T3 cells stably expressing rat 5-HT_2A receptors (EC₅₀ = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.

Compound Libraries for TCB-2

TCB-2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCB-2

M. Wt	353.05
Formula	C₁₁H₁₄BrNO₂.HBr
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	912342-28-0
PubChem ID	71433791
InChi Key	TYMMXVZAUGQKRF-UHFFFAOYSA-N
Smiles	Br.COC1=C2C(CN)CC2=C(OC)C(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCB-2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.83	25
	DMSO	35.3	100

Preparing Stock Solutions for TCB-2

The following data is based on the product molecular weight 353.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.16 mL	28.32 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for TCB-2

References are publications that support the biological activity of the product.

Niebert Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 2011 PMID: 21789169
Fox The serotonin 5-HT_2A receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 2010 PMID: 19823806
McLean 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT_2A receptor agonists. J.Med.Chem. 2006 PMID: 16970404

Citations for TCB-2 (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for TCB-2 include:

Kawai et al. (2022) Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat.Commun.. 13:7708
PMID: 36550097
Afshar et al. (2019) Protective effects of 5-HT_1A receptor antagonist and 5-HT_2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease. J.Chem.Neuroanat.. 96:140
PMID: 30684605
Nagata et al. (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 9:16438
PMID: 31712714
Dong et al. (2016) The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model. Exp Ther Med. 12:3583
PMID: 28101155
Hooper et al. (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol. 311:H572
PMID: 27371685
Gerhold et al. (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 35:9580
PMID: 26134641
Watts et al. (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One. 3:e00103
PMID: 25692021
Goda et al. (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 228:271
PMID: 23525524
Niebert et al. (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. EMBO Mol Med. 6:e21395
PMID: 21789169

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Customer Reviews for TCB-2 (1)

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5-HT has a potential for relaxant

Name: Anonymous

Species: Rat

Assay Type: In Vivo

TCB-2 (5-HT2A)(0.0001 mol/L)

PMID: 25692021

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