TC-SP 14

Tocris Bioscience, part of Bio-Techne | Catalog # 4363

Potent S1P1 receptor agonist
Discontinued Product
4363 has been discontinued. View all Sphingosine-1-phosphate Receptor Agonists products.

Key Product Details

Description

Potent S1P1 receptor agonist

View all Sphingosine-1-phosphate Receptor Agonists »

Product Description

TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Product Specifications

Molecular Weight

450.50

Formula

C25H20F2N2O2S

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid

CAS Number

1257093-40-5

PubChem ID

51346934

InChI Key

GVXGVDIXINMAAL-UHFFFAOYSA-N

SMILES

FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.52 50 with gentle warming

Preparing Stock Solutions for TC-SP 14

The following data is based on the product molecular weight 450.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.44 mL 22.20 mL 44.40 mL
2.5 mM 0.89 mL 4.44 mL 8.88 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
25 mM 0.09 mL 0.44 mL 0.89 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

  • Lanman Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1). ACS Med.Chem.Lett.

Product Documents for TC-SP 14

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-SP 14

For research use only

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