TC-S 7009
Tocris Bioscience, part of Bio-Techne | Catalog # 5243
High affinity and selective HIF-2α inhibitor
Key Product Details
Description
High affinity and selective HIF-2α inhibitor
Product Description
TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.Product Specifications
Molecular Weight
308.65
Formula
C12H6ClFN4O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
CAS Number
1422955-31-4
PubChem ID
70697712
InChI Key
CDQUJZKBRAFWNG-UHFFFAOYSA-N
SMILES
ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.86 | 100 |
Preparing Stock Solutions
for TC-S 7009
The following data is based on the product molecular weight 308.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.20 mL | 32.40 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rogers Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 2013 PMID: 23363003
- Wu Bidirectional modulation of HIF-2 activity through chemical ligands. Nat.Chem.Biol. 2019 PMID: 30804532
- Scheuermann Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 2013 PMID: 23434853
Product Specific Notices for TC-S 7009
For research use only
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