TC-S 7009

Name: TC-S 7009
Brand: Tocris Bioscience
SKU: 5243

Tocris Bioscience, part of Bio-Techne | Catalog # 5243

Citations (10)

COA / SDS

High affinity and selective HIF-2α inhibitor

Key Product Details

Description:	High affinity and selective HIF-2α inhibitor
Chemical Name:	N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	308.65

View Full Technical Details for TC-S 7009

Technical Data
Citations

Biological Activity for TC-S 7009

TC-S 7009 is a high affinity and selective HIF-2α inhibitor (K_d = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

Compound Libraries for TC-S 7009

TC-S 7009 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7009

M. Wt	308.65
Formula	C₁₂H₆ClFN₄O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1422955-31-4
PubChem ID	70697712
InChi Key	CDQUJZKBRAFWNG-UHFFFAOYSA-N
Smiles	ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-S 7009

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.86	100

Preparing Stock Solutions for TC-S 7009

The following data is based on the product molecular weight 308.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.20 mL	32.40 mL
5 mM	0.65 mL	3.24 mL	6.48 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for TC-S 7009

References are publications that support the biological activity of the product.

Rogers Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 2013 PMID: 23363003
Wu Bidirectional modulation of HIF-2 activity through chemical ligands. Nat.Chem.Biol. 2019 PMID: 30804532
Scheuermann Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 2013 PMID: 23434853