TC-S 7005
Tocris Bioscience, part of Bio-Techne | Catalog # 4459
Potent and selective PLK2 inhibitor
Key Product Details
Description
Potent and selective PLK2 inhibitor
Product Description
TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.Product Specifications
Molecular Weight
359.38
Formula
C21H17N3O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
CAS Number
1082739-92-1
PubChem ID
24971422
InChI Key
DAAGOCSHXCDWDY-ZDUSSCGKSA-N
SMILES
C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.94 | 100 |
Preparing Stock Solutions
for TC-S 7005
The following data is based on the product molecular weight 359.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.91 mL | 27.83 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.57 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hanan Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18790636
Product Specific Notices for TC-S 7005
For research use only
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