TC OT 39
Tocris Bioscience, part of Bio-Techne | Catalog # 4625
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
Key Product Details
Description
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
Product Description
TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.Product Specifications
Molecular Weight
600.78
Formula
C32H40N8O2S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
CAS Number
479232-57-0
PubChem ID
135413563
InChI Key
KSNHHKZYKYNBEI-NDEPHWFRSA-N
SMILES
O=C(N5[C@H]([C@](N6CCN(C)CCC6)=S)CCC5)NCC(C(C)=C2)=CC=C2C(N1C(C=CC=C3)=C3NC(N(C)N=C4)=C4C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 100 | ||
| DMSO | 100 |
Preparing Stock Solutions
for TC OT 39
The following data is based on the product molecular weight 600.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.32 mL | 16.65 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pitt Non-peptide oxyt. agonists. Bioorg.Med.Chem.Lett. 2004 PMID: 15357997
- Frantz Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist. J.Med.Chem. 2010 PMID: 20104850
Product Specific Notices for TC OT 39
For research use only
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