TC-MCH 7c
Tocris Bioscience, part of Bio-Techne | Catalog # 4365
Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist
Key Product Details
Description
Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist
Product Description
TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.Product Specifications
Molecular Weight
408.47
Formula
C24H25FN2O3
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
CAS Number
864756-35-4
PubChem ID
11654412
InChI Key
ANCFKYJMXNMYNZ-UHFFFAOYSA-N
SMILES
O=C1C=C(OCC3=CC=C(F)C=C3)C=CN1C2=CC=C(OCCN4CCCC4)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 40.85 | 100 | |
| DMSO | 20.42 | 50 |
Preparing Stock Solutions
for TC-MCH 7c
The following data is based on the product molecular weight 408.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ito Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 2009 PMID: 19836369
- Haga Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 2011 PMID: 21190859
Product Specific Notices for TC-MCH 7c
For research use only
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