TC-I 2014
Tocris Bioscience, part of Bio-Techne | Catalog # 5410
Potent TRPM8 antagonist
Product Description
TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.Product Specifications
Molecular Weight
467.41
Formula
C23H19F6N3O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
CAS Number
1221349-53-6
PubChem ID
45274257
InChI Key
GZINXHRSQAMEQY-ZZEZOPTASA-N
SMILES
FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.74 | 100 | |
| Ethanol | 46.74 | 100 |
Preparing Stock Solutions
for TC-I 2014
The following data is based on the product molecular weight 467.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.70 mL | 21.39 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Parks Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 2011 PMID: 21128593
Product Specific Notices for TC-I 2014
For research use only
Loading...
Loading...