TC-I 15

Name: TC-I 15
Brand: Tocris Bioscience
SKU: 4527

Tocris Bioscience a Bio-Techne Brand

Catalog # 4527

Citations (3)

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Key Product Details

Description:	Potent α₂β₁ inhibitor; displays antithrombotic activity in vivo
Chemical Name:	N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Purity:	≥98% (HPLC)
Molecular Weight:	520.62

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Biological Activity for TC-I 15

TC-I 15 is a potent α₂β₁ integrin inhibitor (IC₅₀ values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α₂β₁ over α_vβ₃, α₅β₁, α₆β₁ and α_IIbβ₃ at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Licensing Information

Sold under license from the University of Pennsylvania.

Technical Data for TC-I 15

M. Wt	520.62
Formula	C₂₃H₂₈N₄O₆S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	916734-43-5
PubChem ID	90488948
InChi Key	XKLHCUGVLCGKKX-RBUKOAKNSA-N
Smiles	CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-I 15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.06	100

Preparing Stock Solutions for TC-I 15

The following data is based on the product molecular weight 520.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.60 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for TC-I 15

References are publications that support the biological activity of the product.

Borza Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 2012 PMID: 22440900
Miller Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19141632

Citations for TC-I 15 (3)

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Citations are publications that use Bio-Techne products. Selected citations for TC-I 15 include:

Hunter et al. (2021) Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol.Appl.Pharmacol.. 428:115669
PMID: 34363821
Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature. 557:714
PMID: 29795344
Li et al. (2018) Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun. 9:3600
PMID: 30190514

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