TC ASK 10

Name: TC ASK 10
Brand: Tocris Bioscience
SKU: 4825

Tocris Bioscience a Bio-Techne Brand

Catalog # 4825

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Key Product Details

Description:	Potent and selective ASK1 inhibitor; orally bioavailable
Chemical Name:	4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	432.35

View Full Technical Details for TC ASK 10

Biological Activity for TC ASK 10

TC ASK 10 is a potent ASK1 inhibitor (IC₅₀ = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC₅₀ = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC₅₀ values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

Compound Libraries for TC ASK 10

TC ASK 10 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TC ASK 10

M. Wt	432.35
Formula	C₂₁H₂₁N₅O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1005775-56-3
PubChem ID	68661090
InChi Key	IKKLFEDUYFZNBO-UHFFFAOYSA-N
Smiles	O=C(C4=CC=C(C(C)(C)C)C=C4)NC1=CN2C(C=CC(N3C=NC=C3)=C2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC ASK 10

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.23	100
	DMSO	43.23	100

Preparing Stock Solutions for TC ASK 10

The following data is based on the product molecular weight 432.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.56 mL	23.13 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for TC ASK 10

References are publications that support the biological activity of the product.

Terao Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg.Med.Chem.Lett. 2012 PMID: 23147077

Citations for TC ASK 10

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