TC-A 2317 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4066

Potent, selective Aurora kinase A inhibitor
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Key Product Details

Description

Potent, selective Aurora kinase A inhibitor

View all Aurora Kinase Inhibitors »

Product Description

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Product Specifications

Molecular Weight

392.93

Formula

C19H28N6O.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

CAS Number

1245907-03-2

PubChem ID

46911725

InChI Key

DXVATYHPJJPMIN-UHFFFAOYSA-N

SMILES

CC1=CC(NC2=NNC(C)=C2)=NC(NC(C)CCCC(C)(C)O)=C1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.29 100
Ethanol 19.65 50

Preparing Stock Solutions for TC-A 2317 hydrochloride

The following data is based on the product molecular weight 392.93

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.72 mL 25.45 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-A 2317 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-A 2317 hydrochloride

For research use only

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