TASP 0277308
Tocris Bioscience, part of Bio-Techne | Catalog # 6498
Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
Key Product Details
Description
Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
Product Description
TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.Product Specifications
Molecular Weight
539.48
Formula
C23H28Cl2N6O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
CAS Number
945725-50-8
PubChem ID
56935569
InChI Key
MVOULGOLHZCXLD-MRXNPFEDSA-N
SMILES
CCN1C(OC2=CC(N3CCN(CC3)C)=CC=C2)=NN=C1[C@H](NS(=O)(C4=CC(Cl)=C(C=C4)Cl)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.7 | 5 |
Preparing Stock Solutions
for TASP 0277308
The following data is based on the product molecular weight 539.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 37.07 mL | 185.36 mL | 370.73 mL |
| 0.25 mM | 7.41 mL | 37.07 mL | 74.15 mL |
| 0.5 mM | 3.71 mL | 18.54 mL | 37.07 mL |
| 2.5 mM | 0.74 mL | 3.71 mL | 7.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fujii Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 2012 PMID: 22387544
- Fujii Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J.Immunol. 2012 PMID: 22131329
Product Specific Notices for TASP 0277308
For research use only
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