Tandospirone hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2854
Selective 5-HT1A partial agonist
Key Product Details
Description
Selective 5-HT1A partial agonist
Alternative Names
SM-3997
Product Description
Tandospirone hydrochloride is a 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.Product Specifications
Molecular Weight
419.95
Formula
C21H29N5O2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
CAS Number
99095-10-0
PubChem ID
13422623
InChI Key
ACVFJYKNBOHIMH-DPFKZJTMSA-N
SMILES
[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.99 | 100 | |
| DMSO | 41.99 | 100 |
Preparing Stock Solutions
for Tandospirone hydrochloride
The following data is based on the product molecular weight 419.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.81 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pollard Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 1992 PMID: 1358655
- Matsubara Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 2006 PMID: 16884702
- Hamik Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 1990 PMID: 1974152
Product Specific Notices for Tandospirone hydrochloride
For research use only
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