TAK 21d

Name: TAK 21d
Brand: Tocris Bioscience
SKU: 5209

Tocris Bioscience, part of Bio-Techne | Catalog # 5209

COA / SDS

Potent FAAH inhibitor

Key Product Details

Description:	Potent FAAH inhibitor
Chemical Name:	4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	397.38

View Full Technical Details for TAK 21d

Technical Data
Citations

Biological Activity for TAK 21d

TAK 21d is a potent FAAH inhibitor; (IC₅₀ values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

Technical Data for TAK 21d

M. Wt	397.38
Formula	C₁₉H₁₇F₂N₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1143578-94-2
PubChem ID	57749996
InChi Key	JCWVFSJNIBAGQN-UHFFFAOYSA-N
Smiles	FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 21d

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.97	10
	1eq. HCl	7.95	20

Preparing Stock Solutions for TAK 21d

The following data is based on the product molecular weight 397.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.58 mL	62.91 mL	125.82 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
2 mM	1.26 mL	6.29 mL	12.58 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

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References for TAK 21d

References are publications that support the biological activity of the product.

Kono Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 2014 PMID: 24440478