T 5224
Tocris Bioscience, part of Bio-Techne | Catalog # 7317
Selective inhibitor of c-Fos/activator protein (AP)-1
Key Product Details
Description
Selective inhibitor of c-Fos/activator protein (AP)-1
Product Description
T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.Product Specifications
Molecular Weight
517.53
Formula
C29H27NO8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[4-(Cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]benzenepropanoic acid
CAS Number
530141-72-1
PubChem ID
23626877
InChI Key
DALCQQSLNPLQFZ-UHFFFAOYSA-N
SMILES
O=C(O)CCC1=CC(=CC=C1OCC2=CC=C3C(=O)NOC3=C2)C(=O)C4=CC=C(OC5CCCC5)C=C4O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.75 | 100 |
Preparing Stock Solutions
for T 5224
The following data is based on the product molecular weight 517.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.66 mL | 19.32 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aikawa Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat.Biotechnol 2008 PMID: 18587386
- Tsuchida Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J.Med.Chem 2006 PMID: 16392794
Product Specific Notices for T 5224
For research use only
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