Swainsonine
Tocris Bioscience, part of Bio-Techne | Catalog # 3208
Inhibitor of α-mannosidase II
Product Description
Swainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.Product Specifications
Molecular Weight
173.21
Formula
C8H15NO3
Storage
Store at -20°C
Chemical Name
(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
CAS Number
72741-87-8
PubChem ID
51683
InChI Key
FXUAIOOAOAVCGD-WCTZXXKLSA-N
SMILES
O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.66 | 50 |
Preparing Stock Solutions
for Swainsonine
The following data is based on the product molecular weight 173.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 11.55 mL | 57.73 mL | 115.47 mL |
| 2.5 mM | 2.31 mL | 11.55 mL | 23.09 mL |
| 5 mM | 1.15 mL | 5.77 mL | 11.55 mL |
| 25 mM | 0.23 mL | 1.15 mL | 2.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Olden The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 1991 PMID: 1754603
- Sun Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 2007 PMID: 17097281
- Tulsiani Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 1982 PMID: 6806288
Product Specific Notices for Swainsonine
For research use only
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