Swainsonine

Name: Swainsonine
Brand: Tocris Bioscience
SKU: 3208

Tocris Bioscience a Bio-Techne Brand

Catalog # 3208

Citations (3)

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Key Product Details

Description:	Inhibitor of α-mannosidase II
Chemical Name:	(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Molecular Weight:	173.21

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Biological Activity for Swainsonine

Swainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

Technical Data for Swainsonine

M. Wt	173.21
Formula	C₈H₁₅NO₃
Storage	Store at -20°C
CAS Number	72741-87-8
PubChem ID	51683
InChi Key	FXUAIOOAOAVCGD-WCTZXXKLSA-N
Smiles	O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Swainsonine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	8.66	50

Preparing Stock Solutions for Swainsonine

The following data is based on the product molecular weight 173.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	11.55 mL	57.73 mL	115.47 mL
2.5 mM	2.31 mL	11.55 mL	23.09 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
25 mM	0.23 mL	1.15 mL	2.31 mL

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References for Swainsonine

References are publications that support the biological activity of the product.

Sun Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 2007 PMID: 17097281
Olden The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 1991 PMID: 1754603
Tulsiani Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 1982 PMID: 6806288

Citations for Swainsonine (3)

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Citations are publications that use Bio-Techne products. Selected citations for Swainsonine include:

Skrenkova et al. (2018) N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci. 11:188
PMID: 29915530
Tareen et al. (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther. 22:575
PMID: 24419083
Nacev et al. (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem. 286:44045
PMID: 22025615

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