Sumatriptan succinate

Name: Sumatriptan succinate
Brand: Tocris Bioscience
SKU: 3586
Rating: 4 (1 reviews)

Catalog # 3586 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (4)

COA / SDS

5-HT1A, 5-HT1B and 5-HT1D agonist

Key Product Details

Description:	5-HT_1A, 5-HT_1B and 5-HT_1D agonist
Alternative Names:	GR 43175
Chemical Name:	3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Purity:	≥99% (HPLC)
Molecular Weight:	413.49

View Full Technical Details for Sumatriptan succinate

Biological Activity for Sumatriptan succinate

Sumatriptan succinate is a 5-HT₁ receptor agonist (K_i values are 17, 27 and 100 nM at 5-HT_1D, 5-HT_1B and 5-HT_1A receptors respectively). Antimigraine agent.

Compound Libraries for Sumatriptan succinate

Sumatriptan succinate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sumatriptan succinate

M. Wt	413.49
Formula	C₁₄H₂₁N₃O₂S.C₄H₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	103628-48-4
PubChem ID	59772
InChi Key	PORMUFZNYQJOEI-UHFFFAOYSA-N
Smiles	O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sumatriptan succinate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	41.35	100
	DMSO	31.01	75

Preparing Stock Solutions for Sumatriptan succinate

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Sumatriptan succinate

References are publications that support the biological activity of the product.

Ottani Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 2004 PMID: 15306203
Peroutka Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 1990 PMID: 2177047
Peroutka and McCarthy Sumatriptan (GR 43175) interacts selectivity with 5-HT_1B and 5-HT_1D binding sites. Eur.J.Pharmacol. 1989 PMID: 2545459

Citations for Sumatriptan succinate (4)

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Citations are publications that use Bio-Techne products. Selected citations for Sumatriptan succinate include:

Veronica A et al. (2022) Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep. 39:110795
PMID: 35545050
Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 175
PMID: 32088264
Leon F et al. (2019) Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide. J Pharmacol Exp Ther. 369:26-36
PMID: 30643015
Matsui & Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 23(13):3852
PMID: 29949769

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Customer Reviews for Sumatriptan succinate (1)

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Inhibition of Synaptic Transmission in the VP

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

sumatriptan (1 μΜ)

PMID: 29949769

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Product Documents for Sumatriptan succinate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.