Sumatriptan succinate

Name: Sumatriptan succinate
Brand: Tocris Bioscience
SKU: 3586
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3586

(1)

Citations (10)

COA / SDS

5-HT1A, 5-HT1B and 5-HT1D agonist

Key Product Details

Description:	5-HT_1A, 5-HT_1B and 5-HT_1D agonist
Alternative Names:	GR 43175
Chemical Name:	3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Purity:	≥99% (HPLC)
Molecular Weight:	413.49

View Full Technical Details for Sumatriptan succinate

Technical Data
Citations / Reviews (1)

Biological Activity for Sumatriptan succinate

Sumatriptan succinate is a 5-HT₁ receptor agonist (K_i values are 17, 27 and 100 nM at 5-HT_1D, 5-HT_1B and 5-HT_1A receptors respectively). Antimigraine agent.

Compound Libraries for Sumatriptan succinate

Sumatriptan succinate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sumatriptan succinate

M. Wt	413.49
Formula	C₁₄H₂₁N₃O₂S.C₄H₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	103628-48-4
PubChem ID	59772
InChi Key	PORMUFZNYQJOEI-UHFFFAOYSA-N
Smiles	O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sumatriptan succinate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	41.35	100
	DMSO	31.01	75

Preparing Stock Solutions for Sumatriptan succinate

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for Sumatriptan succinate

References are publications that support the biological activity of the product.

Peroutka Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 1990 PMID: 2177047
Ottani Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 2004 PMID: 15306203
Peroutka and McCarthy Sumatriptan (GR 43175) interacts selectivity with 5-HT_1B and 5-HT_1D binding sites. Eur.J.Pharmacol. 1989 PMID: 2545459