Sumatriptan succinate
Tocris Bioscience, part of Bio-Techne | Catalog # 3586
5-HT1A, 5-HT1B and 5-HT1D agonist
Key Product Details
Description
5-HT1A, 5-HT1B and 5-HT1D agonist
Alternative Names
GR 43175
Product Description
Sumatriptan succinate is a 5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.Product Specifications
Molecular Weight
413.49
Formula
C14H21N3O2S.C4H6O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
CAS Number
103628-48-4
PubChem ID
59772
InChI Key
PORMUFZNYQJOEI-UHFFFAOYSA-N
SMILES
O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.35 | 100 | |
| DMSO | 31.01 | 75 |
Preparing Stock Solutions
for Sumatriptan succinate
The following data is based on the product molecular weight 413.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.09 mL | 24.18 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Peroutka Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 1990 PMID: 2177047
- Ottani Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 2004 PMID: 15306203
- Peroutka and McCarthy Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 1989 PMID: 2545459
Product Specific Notices for Sumatriptan succinate
For research use only
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