Sumanirole maleate

Name: Sumanirole maleate
Brand: Tocris Bioscience
SKU: 2773

Tocris Bioscience, part of Bio-Techne | Catalog # 2773

Citations (15)

COA / SDS

Selective D2 agonist

Key Product Details

Description:	Selective D₂ agonist
Chemical Name:	(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate
Purity:	≥98% (HPLC)
Molecular Weight:	319.31

View Full Technical Details for Sumanirole maleate

Technical Data
Citations

Biological Activity for Sumanirole maleate

Sumanirole maleate is a high affinity D₂ receptor agonist (EC₅₀ values are between 17 and 75 nM in cell-based assays). Originally reported to exhibit >200-fold selectivity for the D₂ receptor versus other dopamine receptor subtypes (K_i values are 9.0, 1940, >2190 and >7140 for D₂, D₃, D₄ and D₁ receptors respectively). More recently reported to be around 32-fold selective for D₂ over D₃ receptors (K_i values are 17.1 and 546 nM respectively). Exhibits antiParkinsonian activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Sumanirole maleate

Sumanirole maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sumanirole maleate

M. Wt	319.31
Formula	C₁₁H₁₃N₃O.C₄H₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	179386-44-8
PubChem ID	9818478
InChi Key	VOJRMYBBPKNLLI-ORHWHDKWSA-N
Smiles	O=C3N2C1=C(N3)C=CC=C1C[C@@H](NC)C2.O=C(/C=C\C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sumanirole maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.93	100
	DMSO	31.93	100

Preparing Stock Solutions for Sumanirole maleate

The following data is based on the product molecular weight 319.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.32 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for Sumanirole maleate

References are publications that support the biological activity of the product.

Stephenson The effects of a selective DA D₂ receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys. J.Pharmacol.Exp.Ther. 2005 PMID: 15980058
Zou Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) provide clues to DA D₂/D₃ receptor agonist selectivity. J.Med.Chem. 2016 PMID: 27035329
McCall Sumanirole, a highly DA D₂-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 2005 PMID: 15980060