STO-609 acetate is a selective, cell-permeable inhibitor of Ca²⁺-calmodulin-dependent protein kinase kinase (K_i values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of STO-609 acetate is reviewed on the Chemical Probes website.

Product Specifications

Molecular Weight

374.35

Formula

C₁₉H₁₀N₂O₃.C₂H₄O₂

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

CAS Number

1173022-21-3

PubChem ID

16760660

InChI Key

WNRSTFUVBWNELX-UHFFFAOYSA-N

SMILES

CC(O)=O.OC(=O)C1=C2C=CC=C3C(=O)N4C5=CC=CC=C5N=C4C(C=C1)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	100mM NaOH	16.85	45
	DMSO	3.74	10 with sonication

Preparing Stock Solutions for STO-609 acetate

The following data is based on the product molecular weight 374.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.45 mM	5.94 mL	29.68 mL	59.36 mL
2.25 mM	1.19 mL	5.94 mL	11.87 mL
4.5 mM	0.59 mL	2.97 mL	5.94 mL
22.5 mM	0.12 mL	0.59 mL	1.19 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Tokumitsu STO-609, a specific inhibitor of the Ca²⁺/calmodulin-dependent protein kinase kinase. J.Biol.Chem. 2002 PMID: 11867640

STO-609 acetate

Tocris Bioscience, part of Bio-Techne | Catalog # 1551

Key Product Details

Description

View all Calcium Binding Protein Modulator Inhibitors »

Product Description