STF 31
Tocris Bioscience, part of Bio-Techne | Catalog # 4484
NAMPT inhibitor; also GLUT1 inhibitor
Key Product Details
Description
NAMPT inhibitor; also GLUT1 inhibitor
Product Description
STF 31 is an inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.Product Specifications
Molecular Weight
423.53
Formula
C23H25N3O3S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
CAS Number
724741-75-7
PubChem ID
984333
InChI Key
NGQPRVWTFNBUHA-UHFFFAOYSA-N
SMILES
O=C(NC2=CN=CC=C2)C1=CC=C(CNS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.35 | 100 |
Preparing Stock Solutions
for STF 31
The following data is based on the product molecular weight 423.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.36 mL | 11.81 mL | 23.61 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Adams NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 2014 PMID: 25058389
- Kropp Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 2015 PMID: 25834119
- Chan Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 2011 PMID: 21813754
Product Specific Notices for STF 31
For research use only
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