ST 034307

Name: ST 034307
Brand: Tocris Bioscience
SKU: 6271

Tocris Bioscience a Bio-Techne Brand

Catalog # 6271

Citations (3)

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Key Product Details

Description:	Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Chemical Name:	6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	297.95

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Biological Activity for ST 034307

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC₅₀ = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca²⁺/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Technical Data for ST 034307

M. Wt	297.95
Formula	C₁₀H₄Cl₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	133406-29-8
PubChem ID	867466
InChi Key	NTDHYMSVCBGQJF-UHFFFAOYSA-N
Smiles	ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ST 034307

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.8	100
	ethanol	5.96	20

Preparing Stock Solutions for ST 034307

The following data is based on the product molecular weight 297.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.78 mL	33.56 mL
5 mM	0.67 mL	3.36 mL	6.71 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for ST 034307

References are publications that support the biological activity of the product.

Brust Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 2017 PMID: 28223412

Citations for ST 034307 (3)

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Citations are publications that use Bio-Techne products. Selected citations for ST 034307 include:

Giacoletti et al. (2022) A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance. Front.Pharmacol.. 13:935588
PMID: 35899113
Bose et al. (2021) Cross-talk between cAMP and Ca²⁺ signalling in cardiac pacemaker cells involves IP₃-evoked Ca²⁺ release and stimulation of adenylyl cyclase 1. BioRXiv - not yet peer reviewed. 2021;
PMID:
Cheng et al. (2019) Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol.. 98:81
PMID: 30465937

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Product Documents for ST 034307

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.