ST 034307
Tocris Bioscience, part of Bio-Techne | Catalog # 6271
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Key Product Details
Description
Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Product Description
ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.Product Specifications
Molecular Weight
297.95
Formula
C10H4Cl4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
CAS Number
133406-29-8
PubChem ID
867466
InChI Key
NTDHYMSVCBGQJF-UHFFFAOYSA-N
SMILES
ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.8 | 100 | |
| Ethanol | 5.96 | 20 |
Preparing Stock Solutions
for ST 034307
The following data is based on the product molecular weight 297.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.36 mL | 16.78 mL | 33.56 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.71 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brust Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 2017 PMID: 28223412
Product Specific Notices for ST 034307
For research use only
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