SR 9243
Tocris Bioscience, part of Bio-Techne | Catalog # 6138
Selective LXR inverse agonist
Key Product Details
Description
Selective LXR inverse agonist
Product Description
SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.Product Specifications
Molecular Weight
626.62
Formula
C31H32BrNO4S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
CAS Number
1613028-81-1
PubChem ID
76073169
InChI Key
FYQFEJFTCLKXTQ-UHFFFAOYSA-N
SMILES
CC1=CC(C)=CC(C)=C1S(N(CCC2=CC=CC(Br)=C2)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.53 | 20 |
Preparing Stock Solutions
for SR 9243
The following data is based on the product molecular weight 626.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 7.98 mL | 39.90 mL | 79.79 mL |
| 1 mM | 1.60 mL | 7.98 mL | 15.96 mL |
| 2 mM | 0.80 mL | 3.99 mL | 7.98 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Flaveny Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 2015 PMID: 26120082
Product Specific Notices for SR 9243
For research use only
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