SR 9009

Name: SR 9009
Brand: Tocris Bioscience
SKU: 5855

Tocris Bioscience, part of Bio-Techne | Catalog # 5855

Citations (9)

COA / SDS

Rev-Erbα/β agonist

Key Product Details

Description:	Rev-Erbα/β agonist
Chemical Name:	Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	437.94

View Full Technical Details for SR 9009

Technical Data
Citations

Biological Activity for SR 9009

SR 9009 is a Rev-Erbα/β agonist (EC₅₀ = 710 nM; K_d = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.

Compound Libraries for SR 9009

SR 9009 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 9009

M. Wt	437.94
Formula	C₂₀H₂₄ClN₃O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1379686-30-2
PubChem ID	57394020
InChi Key	MMJJNHOIVCGAAP-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 9009

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.79	100
	ethanol	43.79	100

Preparing Stock Solutions for SR 9009

The following data is based on the product molecular weight 437.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.83 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for SR 9009

References are publications that support the biological activity of the product.

Shin Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 2012 PMID: 22633688
Solt Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 2012 PMID: 22460951