SR 9009
Tocris Bioscience, part of Bio-Techne | Catalog # 5855
Rev-Erbα/β agonist
Product Description
SR 9009 is a Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.Product Specifications
Molecular Weight
437.94
Formula
C20H24ClN3O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
CAS Number
1379686-30-2
PubChem ID
57394020
InChI Key
MMJJNHOIVCGAAP-UHFFFAOYSA-N
SMILES
ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.79 | 100 | |
| Ethanol | 43.79 | 100 |
Preparing Stock Solutions
for SR 9009
The following data is based on the product molecular weight 437.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.42 mL | 22.83 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.57 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shin Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 2012 PMID: 22633688
- Solt Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 2012 PMID: 22460951
Product Specific Notices for SR 9009
For research use only
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