SR 59230A hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1511
Potent and selective β3 antagonist
Key Product Details
Description
Potent and selective β3 antagonist
Product Description
SR 59230A hydrochloride is a potent and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3, β1 and β2 receptors respectively). Orally active in vivo.Product Specifications
Molecular Weight
361.91
Formula
C21H27NO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride
CAS Number
1135278-41-9
PubChem ID
24978529
InChI Key
SHUCXUIOEAAJJL-MKSBGGEFSA-N
SMILES
O[C@@H](CN[C@H]2CCCC3=C2C=CC=C3)COC1=C(CC)C=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.62 | 10 | |
| DMSO | 36.19 | 100 |
Preparing Stock Solutions
for SR 59230A hydrochloride
The following data is based on the product molecular weight 361.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.82 mL | 27.63 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mizuno Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 2002 PMID: 11861323
- Manara Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β3) β-adrenoceptors. Pharmacol.Comm.
- Manara Functional identification of rat atypical β-adrenoceptors by the first β3-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 1996 PMID: 8821531
Product Specific Notices for SR 59230A hydrochloride
For research use only
Loading...
Loading...