SR 59230A hydrochloride

Name: SR 59230A hydrochloride
Brand: Tocris Bioscience
SKU: 1511

Catalog # 1511 | Tocris Bioscience a Bio-Techne Brand

Citations (14)

COA / SDS

Potent and selective β3 antagonist

Key Product Details

Description:	Potent and selective β₃ antagonist
Chemical Name:	1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	361.91

View Full Technical Details for SR 59230A hydrochloride

Technical Data
Citations (14) / Reviews

Biological Activity for SR 59230A hydrochloride

SR 59230A hydrochloride is a potent and selective β₃ adrenoceptor antagonist (IC₅₀ values are 40, 408 and 648 nM for β₃, β₁ and β₂ receptors respectively). Orally active in vivo.

Compound Libraries for SR 59230A hydrochloride

SR 59230A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 59230A hydrochloride

M. Wt	361.91
Formula	C₂₁H₂₇NO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1135278-41-9
PubChem ID	24978529
InChi Key	SHUCXUIOEAAJJL-MKSBGGEFSA-N
Smiles	O[C@@H](CN[C@H]2CCCC3=C2C=CC=C3)COC1=C(CC)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 59230A hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.62	10
	DMSO	36.19	100

Preparing Stock Solutions for SR 59230A hydrochloride

The following data is based on the product molecular weight 361.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.82 mL	27.63 mL
5 mM	0.55 mL	2.76 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for SR 59230A hydrochloride

References are publications that support the biological activity of the product.

Mizuno Stimulation of β₃-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 2002 PMID: 11861323
Manara Functional identification of rat atypical β-adrenoceptors by the first β₃-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 1996 PMID: 8821531
Manara Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β₃) β-adrenoceptors. Pharmacol.Comm.

Citations for SR 59230A hydrochloride (14)

Showing 1 - 10 of 14 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SR 59230A hydrochloride include:

González-García et al. (2018) E2 Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep. 25:413
PMID: 30304681
Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 58(1):299
PMID: 28114591
Martínez-Sánchez et al. (2017) Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 26:212
PMID: 28683288
Armaiz-Pena et al. (2015) Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 6:4266
PMID: 25738355
Sun et al. (2015) Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. J Neuroimmunol. 5:15950
PMID: 26516061
Lavine et al. (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 131:376
PMID: 23303344
Ataka et al. (2013) Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS One. 8:e81744
PMID: 24303068
Brosnahan et al. (2013) NE potentiates proinflammatory responses of human vaginal epithelial cells. J Neurosci. 259:42583
PMID: 23571017
Rankovic et al. (2011) Modulation of calcium-dependent inactivation of L-type Ca²⁺ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One. 6:e27474
PMID: 22164209
Enriori et al. (2011) Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. Mamm Genome. 31:12189
PMID: 21865462
Sood et al. (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 120:1515
PMID: 20389021
Maupoil et al. (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 150:899
PMID: 17325650
Nackley et al. (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 128:199
PMID: 17084978
Cirino et al. (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Sci Rep. 100:5531
PMID: 12707413

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