SR 27897

Name: SR 27897
Brand: Tocris Bioscience
SKU: 2190

Catalog # 2190 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Potent and selective CCK1 antagonist

Key Product Details

Description:	Potent and selective CCK₁ antagonist
Alternative Names:	Lintitript
Chemical Name:	2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	411.86

View Full Technical Details for SR 27897

Technical Data
Citations (1) / Reviews

Biological Activity for SR 27897

SR 27897 is a potent, non-peptide CCK₁ receptor antagonist that displays > 33-fold selectivity over CCK₂ receptors (EC₅₀ values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Compound Libraries for SR 27897

SR 27897 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 27897

M. Wt	411.86
Formula	C₂₀H₁₄ClN₃O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	136381-85-6
PubChem ID	122077
InChi Key	ILNRQFBVVQUOLP-UHFFFAOYSA-N
Smiles	OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 27897

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.59	50

Preparing Stock Solutions for SR 27897

The following data is based on the product molecular weight 411.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.86 mL	24.28 mL	48.56 mL
2.5 mM	0.97 mL	4.86 mL	9.71 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
25 mM	0.10 mL	0.49 mL	0.97 mL

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References for SR 27897

References are publications that support the biological activity of the product.

Cano Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 2003 PMID: 14534148
Gouldson Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 1999 PMID: 10594328
Gully Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol.

Citations for SR 27897 (1)

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Citations are publications that use Bio-Techne products. Selected citations for SR 27897 include:

Wu et al. (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci. 138:278
PMID: 24385417

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