SR 2211
Tocris Bioscience, part of Bio-Techne | Catalog # 4869
Selective RORγ inverse agonist
Key Product Details
Description
Selective RORγ inverse agonist
Product Description
SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.Licensing Information
Sold under license from The Scripps Research Institute.Product Specifications
Molecular Weight
527.48
Formula
C26H24F7N3O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
CAS Number
1359164-11-6
PubChem ID
51035449
InChI Key
KVHKWAZUPPBMLL-UHFFFAOYSA-N
SMILES
FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.75 | 100 |
Preparing Stock Solutions
for SR 2211
The following data is based on the product molecular weight 527.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.48 mL | 18.96 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kumar Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 2012 PMID: 22292739
Product Specific Notices for SR 2211
For research use only
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