SR 12813

Tocris Bioscience, part of Bio-Techne | Catalog # 2969

Pregnane X receptor agonist
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Key Product Details

Description

Pregnane X receptor agonist

View all Pregnane X Receptor Agonists »

Product Description

SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.

Product Specifications

Molecular Weight

504.53

Formula

C24H42O7P2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester

CAS Number

126411-39-0

PubChem ID

446313

InChI Key

YQLJDECYQDRSBI-UHFFFAOYSA-N

SMILES

OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.45 100
Ethanol 50.45 100

Preparing Stock Solutions for SR 12813

The following data is based on the product molecular weight 504.53

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.40 mL 1.98 mL 3.96 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SR 12813

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 12813

For research use only

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