SR 1078

Name: SR 1078
Brand: Tocris Bioscience
SKU: 4874

Tocris Bioscience, part of Bio-Techne | Catalog # 4874

Citations (13)

COA / SDS

RORα/γ agonist

Key Product Details

Description:	RORα/γ agonist
Chemical Name:	N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	431.25

View Full Technical Details for SR 1078

Technical Data
Citations

Biological Activity for SR 1078

SR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries for SR 1078

SR 1078 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 1078

M. Wt	431.25
Formula	C₁₇H₁₀F₉NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1246525-60-9
PubChem ID	17980288
InChi Key	DUXWIYXHHGNUJU-UHFFFAOYSA-N
Smiles	OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1NC(C2=CC=C(C(F)(F)F)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 1078

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.12	100
	ethanol	43.12	100

Preparing Stock Solutions for SR 1078

The following data is based on the product molecular weight 431.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.19 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for SR 1078

References are publications that support the biological activity of the product.

Wang Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 2012 PMID: 22509368
Wang Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 2010 PMID: 20735016