Spermine tetrahydrochloride

Name: Spermine tetrahydrochloride
Brand: Tocris Bioscience
SKU: 0958

Tocris Bioscience a Bio-Techne Brand

Catalog # 0958

Citations (8)

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Key Product Details

Description:	Modulator at polyamine site
Chemical Name:	N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Molecular Weight:	348.19

View Full Technical Details for Spermine tetrahydrochloride

Biological Activity for Spermine tetrahydrochloride

Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data for Spermine tetrahydrochloride

M. Wt	348.19
Formula	C₁₀H₂₆N₄.4HCl
Storage	Desiccate at +4°C
CAS Number	306-67-2
PubChem ID	9384
InChi Key	XLDKUDAXZWHPFH-UHFFFAOYSA-N
Smiles	NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Spermine tetrahydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	34.82	100

Preparing Stock Solutions for Spermine tetrahydrochloride

The following data is based on the product molecular weight 348.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.36 mL	28.72 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for Spermine tetrahydrochloride

References are publications that support the biological activity of the product.

Doyle and Shaw Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 1998 PMID: 9641557
Johnson Modulation of channel function by polyamines. TiPS 1996 PMID: 8789355
Benveniste and Mayer Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 1993 PMID: 8229795
Munir Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 1993 PMID: 8358608

Citations for Spermine tetrahydrochloride (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Spermine tetrahydrochloride include:

Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron. 95:1129
PMID: 28823727
McGee et al. (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci. 35:16171
PMID: 26658868
Quintana et al. (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A. 593:4373
PMID: 26174503
Soto et al. (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci. 34:11673
PMID: 25164663
Zonouzi et al. (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci. 14:1430
PMID: 21983683
Biase et al. (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol. 31:12650
PMID: 21880926
Soto et al. (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci. 12:277
PMID: 19234459
Campioni et al. (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci. 101:3192
PMID: 19357347

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