Sotalol hydrochloride

Name: Sotalol hydrochloride
Brand: Tocris Bioscience
SKU: 0952
Price: 76 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0952

Citations (3)

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Key Product Details

Description:	β antagonist
Chemical Name:	N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	308.82

View Full Technical Details for Sotalol hydrochloride

Biological Activity for Sotalol hydrochloride

Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

Technical Data for Sotalol hydrochloride

M. Wt	308.82
Formula	C₁₂H₂₀N₂O₃S.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	959-24-0
PubChem ID	66245
InChi Key	VIDRYROWYFWGSY-UHFFFAOYSA-N
Smiles	Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sotalol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.44	50

Preparing Stock Solutions for Sotalol hydrochloride

The following data is based on the product molecular weight 308.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.48 mL	32.38 mL	64.76 mL
2.5 mM	1.30 mL	6.48 mL	12.95 mL
5 mM	0.65 mL	3.24 mL	6.48 mL
25 mM	0.13 mL	0.65 mL	1.30 mL

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References for Sotalol hydrochloride

References are publications that support the biological activity of the product.

Fiset Block of I_ks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 1997 PMID: 9336319
Claudel and Touboul Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 1995 PMID: 7770366
Uloth Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 1966 PMID: 6006227

Citations for Sotalol hydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for Sotalol hydrochloride include:

McKeithan et al. (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 8:766
PMID: 29075196
Kaya et al. (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci. 329:350
PMID: 19144685
Woo et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 54:599
PMID: 17521572

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Product Documents for Sotalol hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.