SNS 032

Product Description

SNS 032 is a cyclin dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC₅₀ >1 μM). Arrests the cell cycle at G₂/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Solubility

Preparing Stock Solutions for SNS 032

The following data is based on the product molecular weight 380.53

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.26 mL	26.28 mL	52.56 mL
2.5 mM	1.05 mL	5.26 mL	10.51 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
25 mM	0.11 mL	0.53 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Chen Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 2010 PMID: 20663900
• Ali SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 2007 PMID: 17534442
• Conroy SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol. 2009 PMID: 19169685
• Misra N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J.Med.Chem. 2004 PMID: 15027863