SNC 80

Tocris Bioscience a Bio-Techne Brand

Catalog # 0764

Citations (18)

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Key Product Details

Description:	Highly selective non-peptide δ agonist
Chemical Name:	(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	449.64

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Biological Activity for SNC 80

SNC 80 is a highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.

Compound Libraries for SNC 80

SNC 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SNC 80

M. Wt	449.64
Formula	C₂₈H₃₉N₃O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	156727-74-1
PubChem ID	123924
InChi Key	KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Smiles	[H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC=CC(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNC 80

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	44.96	100 with gentle warming
	DMSO	8.99	20

Preparing Stock Solutions for SNC 80

The following data is based on the product molecular weight 449.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.12 mL	22.24 mL
5 mM	0.44 mL	2.22 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for SNC 80

References are publications that support the biological activity of the product.

Knapp Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 1996 PMID: 8667189
Bilsky SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 1995 PMID: 7714789
Calderon Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid J.Med.Chem. 1994 PMID: 8035418

Citations for SNC 80 (18)

Showing 1 - 10 of 18 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SNC 80 include:

Wang et al. (2018) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 98:90
PMID: 29576387
Robins et al. (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry. 9:112
PMID: 29686629
Ye (2017) Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice. Neuroscience. 363:50
PMID: 28673713
Ong et al. (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Front Endocrinol (Lausanne). 172:615
PMID: 24819092
Levoye et al. (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Brain Struct Funct. 6:167
PMID: 26617570
Erbs et al. (2015) A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. J Neurosci. 220:677
PMID: 24623156
Schuster et al. (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Transl Oncol. 172:642
PMID: 24827408
Neumann et al. (2015) The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol. 135:471
PMID: 25178105
Pradhan et al. (2014) δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol. 171:2375
PMID: 24467301
Milan-Lobo et al. (2013) Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One. 8:e58362
PMID: 23554887
Burbassi et al. (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci. 32:1278
PMID: 20880358
Butelman et al. (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl). 210:253
PMID: 20084367
Pacheco et al. (2009) Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol. 158:225
PMID: 19594755
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem. 283:29086
PMID: 18703511
Pacheco et al. (2008) The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol. 154:1143
PMID: 18469844
Scherrer et al. (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A. 103:9691
PMID: 16766653
Sluka et al. (2002) Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J Pharmacol Exp Ther. 302:1146
PMID: 12183674
Gomes et al. (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Br J Pharmacol. 20:RC110
PMID: 11069979

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Product Documents for SNC 80

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Certificate of Analysis

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