SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t_½ of 37h.

Technical Data

M. Wt	220.24
Formula	C₇H₁₂N₂O₄S
Storage	Store at -20°C
CAS Number	79032-48-7
PubChem ID	5231
InChi Key	ZIIQCSMRQKCOCT-UHFFFAOYSA-N
Smiles	O=NSC(C)(C)C(NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.02	100

Preparing Stock Solutions

The following data is based on the product molecular weight 220.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.54 mL	22.70 mL	45.41 mL
5 mM	0.91 mL	4.54 mL	9.08 mL
10 mM	0.45 mL	2.27 mL	4.54 mL
50 mM	0.09 mL	0.45 mL	0.91 mL

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References

References are publications that support the biological activity of the product.

Bauer and Fung Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 1991 PMID: 1899118
Cross Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 1994 PMID: 7969812
Ekblad and Sundler Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 1997 PMID: 9336304
Ferrero Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 1999 PMID: 10401570

Citations (10)

Showing 1 - 10 of 10 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SNAP include:

Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife. 6:e23786
PMID: 28402252
Sánchez et al. (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol. 171:5682
PMID: 25091502
Rodríguez-Muñoz et al. (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal. 14:2413
PMID: 21235400
Cheng et al. (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett. 585:328
PMID: 21156174
Sunters et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem. 285:8743
PMID: 20042609
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 20:982
PMID: 19666830
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol. 97:3386
PMID: 17376843
Sachs et al. (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A. 101:3680
PMID: 14990791
Nistri et al. (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med. 4:32
PMID: 12734571
Fedele et al. (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol. 119:590
PMID: 8894183

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JNK-dependent rescue of LTPGABA by acute norBNI

Name: Anonymous

Species: Rat

Assay Type: In Vivo

Cell Line/Tissue: brain

IPSCs used before and 15 min after drug application (SNAP, 400 µM)

PMID: 28402252

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Product Documents

COA

Certificate of Analysis

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SNAP

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Biological Activity