SMER 28

Product Description

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Solubility

Preparing Stock Solutions for SMER 28

The following data is based on the product molecular weight 264.12

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.79 mL	18.93 mL	37.86 mL
5 mM	0.76 mL	3.79 mL	7.57 mL
10 mM	0.38 mL	1.89 mL	3.79 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sarkar Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 2010 PMID: 17486044
• Zhang Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 2016 PMID: 27133794
• Renna Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 2010 PMID: 20147746