SLM 6031434 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6281
Selective sphingosine kinase 2 (Sphk2) inhibitor
Key Product Details
Description
Selective sphingosine kinase 2 (Sphk2) inhibitor
Product Description
SLM 6031434 hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice .Licensing Information
Sold with the permission of the University of Virginia Patent FoundationProduct Specifications
Molecular Weight
489.96
Formula
C22H30F3N5O2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
CAS Number
1897379-34-8
PubChem ID
134812833
InChI Key
YIGAQKBPLMSWOD-LMOVPXPDSA-N
SMILES
CCCCCCCCOC1=C(C(F)(F)F)C=C(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.8 | 20 | |
| DMSO | 49 | 100 |
Preparing Stock Solutions
for SLM 6031434 hydrochloride
The following data is based on the product molecular weight 489.96
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.20 mL | 20.41 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schwalm Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 2021 PMID: 33301900
- Kharel Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 2015 PMID: 26243740
Product Specific Notices for SLM 6031434 hydrochloride
For research use only
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