SL 327 is a selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Product Specifications

Molecular Weight

335.35

Formula

C₁₆H₁₂F₃N₃S

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

CAS Number

305350-87-2

PubChem ID

9549284

InChI Key

JLOXTZFYJNCPIS-FYWRMAATSA-N

SMILES

N\C(SC1=CC=C(N)C=C1)=C(\C#N)C1=CC=CC=C1C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.53	100
	Ethanol	16.77	50

Preparing Stock Solutions for SL 327

The following data is based on the product molecular weight 335.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Atkins The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1998 PMID: 10196568
Scherle Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 2000 PMID: 10969080
Wang Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 2003 PMID: 12490588
Davis The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 2000 PMID: 10844026

SL 327

Tocris Bioscience, part of Bio-Techne | Catalog # 1969

Key Product Details

Description

View all MEK Inhibitors »

Product Description