SKF 38393 hydrobromide

Name: SKF 38393 hydrobromide
Brand: Tocris Bioscience
SKU: 0922

Tocris Bioscience a Bio-Techne Brand

Catalog # 0922

Citations (18)

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Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	336.23

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Biological Activity for SKF 38393 hydrobromide

SKF 38393 hydrobromide is a prototypical D₁-like dopamine receptor selective partial agonist (K_i values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D₁, D₅, D₂, D₃ and D₄ receptors respectively).

Technical Data for SKF 38393 hydrobromide

M. Wt	336.23
Formula	C₁₆H₁₇NO₂.HBr
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	20012-10-6
PubChem ID	12928470
InChi Key	INNWVRBZMBCEJI-UHFFFAOYSA-N
Smiles	Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 38393 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.41	25 with gentle warming
	DMSO	33.62	100

Preparing Stock Solutions for SKF 38393 hydrobromide

The following data is based on the product molecular weight 336.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.87 mL	29.74 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for SKF 38393 hydrobromide

References are publications that support the biological activity of the product.

Geter-Douglass Characterization of unconditioned behavioral effects of DA D₃/D₂ receptor agonists. J.Pharmacol.Exp.Ther. 1997 PMID: 9336302
Habuchi DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 1997 PMID: 9422813
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
Sibley Interactions of novel DArgic ligands with D₁ and D₂ DA receptors. Life Sci. 1982 PMID: 6127585

Citations for SKF 38393 hydrobromide (18)

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Citations are publications that use Bio-Techne products. Selected citations for SKF 38393 hydrobromide include:

Zhang et al. (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci. 59(11):4441
PMID: 30193315
Zike (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. Proc Natl Acad Sci USA. 114(22):5719
PMID: 28507136
Mi (2017) Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor. Plos One. 12:e0168964
PMID: 28085967
Grochowska et al. (2017) Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep. 18:962
PMID: 28420656
Tozzi et al. (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci. 9:192
PMID: 26074768
Xing et al. (2015) DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Eur J Neurosci. 9:310
PMID: 26388722
Polito et al. (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Immunol. 2
PMID: 26465004
Toro et al. (2015) DA Modulates the Activity of Sensory Hair Cells. J Neurosci. 35:16494
PMID: 26674873
Moreno et al. (2014) Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 34:3545
PMID: 24599455
Cilz et al. (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 24:3195
PMID: 23843440
Jia et al. (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci. 16:1627
PMID: 24121738
Murugan et al. (2013) Diminished FoxP2 levels affect DArgic modulation of corticostriatal signaling important to song variability. Neuron. 80:1464
PMID: 24268418
Hook et al. (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Eneuro. 35:507
PMID: 22304466
Prado et al. (2012) Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Biol Chem. 188:3062
PMID: 22379034
Herwerth et al. (2012) D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex. 22:1786
PMID: 21955919
Burgess et al. (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep. 33:1295
PMID: 21061851
Marcellino et al. (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Front Neurosci. 283:26016
PMID: 18644790
Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology. 55:871
PMID: 18644393

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