SKF 38393 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0922
Selective D1-like agonist
Key Product Details
Description
Selective D1-like agonist
Product Description
SKF 38393 hydrobromide is a prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).Product Specifications
Molecular Weight
336.23
Formula
C16H17NO2.HBr
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
CAS Number
20012-10-6
PubChem ID
12928470
InChI Key
INNWVRBZMBCEJI-UHFFFAOYSA-N
SMILES
Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.41 | 25 with gentle warming | |
| DMSO | 33.62 | 100 |
Preparing Stock Solutions
for SKF 38393 hydrobromide
The following data is based on the product molecular weight 336.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sibley Interactions of novel DArgic ligands with D1 and D2 DA receptors. Life Sci. 1982 PMID: 6127585
- Habuchi DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 1997 PMID: 9422813
- Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
- Geter-Douglass Characterization of unconditioned behavioral effects of DA D3/D2 receptor agonists. J.Pharmacol.Exp.Ther. 1997 PMID: 9336302
Product Specific Notices for SKF 38393 hydrobromide
For research use only
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