SK 216

Tocris Bioscience, part of Bio-Techne | Catalog # 6187

Plasminogen activator inhibitor-1 (PAI-1) inhibitor
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Key Product Details

Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

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Product Description

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Product Specifications

Molecular Weight

533.52

Formula

C29H29NO6Na2

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

CAS Number

654080-03-2

PubChem ID

131954585

InChI Key

YYTGMMYYLGKWIK-UHFFFAOYSA-L

SMILES

CC(C)(C)C1=CC=C(OC(C2=CC(C=CC(OCCCCCC(C(O[Na])=O)C(O[Na])=O)=C3)=C3C=C2)=N4)C4=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.67 5 with gentle warming

Preparing Stock Solutions for SK 216

The following data is based on the product molecular weight 533.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 37.49 mL 187.43 mL 374.87 mL
0.25 mM 7.50 mL 37.49 mL 74.97 mL
0.5 mM 3.75 mL 18.74 mL 37.49 mL
2.5 mM 0.75 mL 3.75 mL 7.50 mL

Calculators

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Reconstitution Calculator

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Product Documents for SK 216

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SK 216

For research use only

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