SJ 3149

Product Description

SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC₅₀ = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC₅₀ = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC₅₀ = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Solubility

Preparing Stock Solutions for SJ 3149

The following data is based on the product molecular weight 376.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.57 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nishiguchi Selective CK1a degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat.Commun. 2024 PMID: 38228616