SJ 1008030
Tocris Bioscience, part of Bio-Techne | Catalog # 7675
Selective JAK2 Degrader (PROTAC®)
Product Description
SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC®). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels.JAK2 antibodies validated for Western Blot also available: Catalog # NBP2-59451 and AF2988.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from St. Jude Children's Research HospitalProduct Specifications
Molecular Weight
987.97
Formula
C42H43N13O7S.CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
CAS Number
2863634-97-1
InChI Key
RRJQTSMHAOAMTD-UHFFFAOYSA-N
SMILES
CCS(=O)(N1CC(C1)(N2C=C(C3=C4C=CNC4=NC(NC5=CC=C(C(NCCN6CCN(C7=CC=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)CC6)=O)C=C5)=N3)C=N2)CC#N)=O.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.4 | 50 |
Preparing Stock Solutions
for SJ 1008030
The following data is based on the product molecular weight 987.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.02 mL | 10.12 mL | 20.24 mL |
| 2.5 mM | 0.40 mL | 2.02 mL | 4.05 mL |
| 5 mM | 0.20 mL | 1.01 mL | 2.02 mL |
| 25 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Constantinescu Degrading JAK2 in ALL by ruxolitinib-based PROTACs. Blood 2021 PMID: 34882211
- Chang Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood 2021 PMID: 34110416
Product Specific Notices for SJ 1008030
For research use only
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