SirReal 2
Tocris Bioscience, part of Bio-Techne | Catalog # 5457
Selective inhibitor of SIRT2
Key Product Details
Description
Selective inhibitor of SIRT2
Product Description
SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.Product Specifications
Molecular Weight
420.55
Formula
C22H20N4OS2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
CAS Number
709002-46-0
PubChem ID
1096292
InChI Key
MENNDDDTIIZDDN-UHFFFAOYSA-N
SMILES
CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.05 | 100 |
Preparing Stock Solutions
for SirReal 2
The following data is based on the product molecular weight 420.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rumpf Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 2015 PMID: 25672491
Product Specific Notices for SirReal 2
For research use only
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