SIN-1 chloride

Name: SIN-1 chloride
Brand: Tocris Bioscience
SKU: 0756
Rating: 5 (1 reviews)

Catalog # 0756

Citations (1)

(1)

COA / SDS

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Key Product Details

Description:	Water-soluble NO donor
Alternative Names:	3-Morpholinylsydnoneimine chloride
Chemical Name:	Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	206.63

View Full Technical Details for SIN-1 chloride

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

M. Wt	206.63
Formula	C₆H₁₁ClN₄O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	16142-27-1
PubChem ID	197942
InChi Key	ZRFWHHCXSSACAW-UHFFFAOYSA-M
Smiles	NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.66	100
	DMSO	20.66	100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.84 mL	24.20 mL	48.40 mL
5 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.48 mL	2.42 mL	4.84 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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References

References are publications that support the biological activity of the product.

Siegfried Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 1992 PMID: 1738117
Maurice and Heslam Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 1990 PMID: 2160060
Nishikawa Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 1982 PMID: 6118429
Tanayama Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica

Citations for SIN-1 chloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for SIN-1 chloride include:

Mistry and Garland (1998) Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol. 124:1131
PMID: 9720783

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SIN-1 inhibits the chlorinating activity of MPO

Name: Christopher Trummer

Species: Other

Assay Type: In Vitro

Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. Fluorescence intensities were measured every 30 s (up to 30 min) at 488/522 nm (excitation/emission wavelength) at 37 °C. SIN-1 inhibits the chlorinating capacity of MPO.

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