SIN-1 chloride

Name: SIN-1 chloride
Brand: tocris
SKU: 0756
Rating: 5 (1 reviews)

Catalog # 0756

Citations (1)

(1)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Water-soluble NO donor
Alternative Names:	3-Morpholinylsydnoneimine chloride
Chemical Name:	Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	206.63

View Full Technical Details for SIN-1 chloride

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

M. Wt	206.63
Formula	C₆H₁₁ClN₄O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	16142-27-1
PubChem ID	197942
InChi Key	ZRFWHHCXSSACAW-UHFFFAOYSA-M
Smiles	NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.66	100
	DMSO	20.66	100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.84 mL	24.20 mL	48.40 mL
5 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.48 mL	2.42 mL	4.84 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Maurice and Heslam Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 1990 PMID: 2160060
Nishikawa Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 1982 PMID: 6118429
Siegfried Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 1992 PMID: 1738117
Tanayama Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica

Citations (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for SIN-1 chloride include:

Mistry and Garland (1998) Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol. 124:1131
PMID: 9720783

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Customer Reviews (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

SIN-1 inhibits the chlorinating activity of MPO

Name: Christopher Trummer

Species: Other

Assay Type: In Vitro

Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. Fluorescence intensities were measured every 30 s (up to 30 min) at 488/522 nm (excitation/emission wavelength) at 37 °C. SIN-1 inhibits the chlorinating capacity of MPO.

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SIN-1 chloride

Order Information

Shipping Information

Key Product Details

Complete Your Research

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Customer Reviews (1)

Customer Images

SIN-1 inhibits the chlorinating activity of MPO

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected