SID 7969543
Tocris Bioscience, part of Bio-Techne | Catalog # 3440
Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Key Product Details
Description
Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Product Description
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).Product Specifications
Molecular Weight
452.46
Formula
C24H24N2O7
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
CAS Number
868224-64-0
PubChem ID
4076092
InChI Key
KWMBIIQCLUIHDI-UHFFFAOYSA-N
SMILES
O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.25 | 100 |
Preparing Stock Solutions
for SID 7969543
The following data is based on the product molecular weight 452.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.10 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Madoux Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 2008 PMID: 18334597
- Roth Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 2008 PMID: 18374567
Product Specific Notices for SID 7969543
For research use only
Loading...
Loading...