SGC GAK 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6564

High affinity cyclin G associated kinase (GAK) inhibitor
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Key Product Details

Description

High affinity cyclin G associated kinase (GAK) inhibitor

View all Other Kinase Inhibitors »

Product Description

SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor (Kd = 1.9 nM). Exhibits >30-fold selectivity for GAK over a panel of other kinases. Inhibits GAK in live cell assays (IC50 = 110 nM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC GAK 1 probe summary on the SGC website.

Product Specifications

Molecular Weight

389.24

Formula

C18H17BrN2O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine

CAS Number

2226517-76-4

PubChem ID

50877865

InChI Key

JVUVMZJTEXYQNS-UHFFFAOYSA-N

SMILES

BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.92 100
Ethanol 19.46 50

Preparing Stock Solutions for SGC GAK 1

The following data is based on the product molecular weight 389.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.85 mL 25.69 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SGC GAK 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SGC GAK 1

For research use only

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