SGC CAMKK2-1

Tocris Bioscience, part of Bio-Techne | Catalog # 7877

Potent and selective CAMKK1/2 inhibitor
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Key Product Details

Description

Potent and selective CAMKK1/2 inhibitor

View all Calcium Binding Protein Modulator Inhibitors »

Product Description

SGC CAMKK2-1 is a potent and selective Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (CAMKK2 IC50 = 30 nM). Displays selectivity toward CAMKK1 and CAMKK2 over 404 kinases in a kinome wide screen (Discoverx). SGC CAMKK2-1 inhibits AMPK phosphorylation in C4-2 prostate cancer cells (IC50 = 1.6 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CAMKK2-1 probe summary on the SGC website.

Product Specifications

Molecular Weight

397.47

Formula

C26H23NO3

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2-Cyclopentyl-4-[5-(3-methylphenyl)furo[2,3-b]pyridin-3-yl]benzoic acid

CAS Number

2561494-76-4

PubChem ID

154700451

InChI Key

TXIYVFVMXNFNRX-UHFFFAOYSA-N

SMILES

O=C(C1=C(C2CCCC2)C=C(C3=COC4=NC=C(C5=CC(C)=CC=C5)C=C43)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.75 100

Preparing Stock Solutions for SGC CAMKK2-1

The following data is based on the product molecular weight 397.47

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.50 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SGC CAMKK2-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SGC CAMKK2-1

For research use only

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