SGC 6870

Name: SGC 6870
Brand: Tocris Bioscience
SKU: 7182

Tocris Bioscience, part of Bio-Techne | Catalog # 7182

COA / SDS

Potent and selective PRMT6 allosteric inhibitor

Key Product Details

Chemical Name:	(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
Purity:	≥98%

View Full Technical Details for SGC 6870

Technical Data
Citations

Biological Activity for SGC 6870

SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC₅₀ = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC₅₀ = 0.8 μM)

Negative control SGC 6870N (Cat. No. 7184) also available.

Technical Data for SGC 6870

Formula	C₂₃H₂₁BrN₂O₂S
Storage	Store at -20°C
Purity	≥98%
CAS Number	2561471-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC 6870

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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Product Documents for SGC 6870

COA

Certificate of Analysis

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