SGC 6870
Tocris Bioscience, part of Bio-Techne | Catalog # 7182
Potent and selective PRMT6 allosteric inhibitor
Key Product Details
Description
Potent and selective PRMT6 allosteric inhibitor
Product Description
SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM)Negative control SGC 6870N (Cat. No. 7184) also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 6870 probe summary on the SGC website.Product Specifications
Molecular Weight
469.40
Formula
C23H21BrN2O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS Number
2561471-27-8
PubChem ID
146026048
InChI Key
NIPTUMFVYBXSMZ-JOCHJYFZSA-N
SMILES
CC1=CC=C2C([C@@H](C3=CC(C)=CC(C)=C3)N(C(C4=CC=C(Br)S4)=O)CC(N2)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.94 | 100 | |
| Ethanol | 46.94 | 100 |
Preparing Stock Solutions
for SGC 6870
The following data is based on the product molecular weight 469.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.65 mL | 21.30 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shen A first-in-class, highly selective and cell-active allosteric inhibitor of protein arginine methyltransferase 6 (PRMT6) J.Med.Chem. 2021 PMID: 33591753
Product Specific Notices for SGC 6870
For research use only
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