SF 11
Tocris Bioscience, part of Bio-Techne | Catalog # 3898
NPY Y2 receptor antagonist
Product Description
SF 11 is an NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.Product Specifications
Molecular Weight
446.60
Formula
C27H30N2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
CAS Number
443292-81-7
PubChem ID
2936384
InChI Key
PMEQBGAGFZDWQX-UHFFFAOYSA-N
SMILES
S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.66 | 100 | |
| Ethanol | 22.33 | 50 |
Preparing Stock Solutions
for SF 11
The following data is based on the product molecular weight 446.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.20 mL | 22.39 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Domin Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem.Neurosci. 2019 PMID: 31267743
- Brothers Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 2010 PMID: 19837904
Product Specific Notices for SF 11
For research use only
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