Senexin A
Tocris Bioscience, part of Bio-Techne | Catalog # 4875
Cdk8 inhibitor
Key Product Details
Description
Cdk8 inhibitor
Product Description
Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.Licensing Information
Sold under license from Senex Biotechnology.Product Specifications
Molecular Weight
310.78
Formula
C17H14N4.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
CAS Number
1780390-76-2
PubChem ID
90488980
InChI Key
POENYXHGUHRXFR-UHFFFAOYSA-N
SMILES
N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.08 | 100 |
Preparing Stock Solutions
for Senexin A
The following data is based on the product molecular weight 310.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.09 mL | 32.18 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Porter Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22869755
Product Specific Notices for Senexin A
For research use only
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