Semax

Name: Semax
Brand: Tocris Bioscience
SKU: 7712

Tocris Bioscience, part of Bio-Techne | Catalog # 7712

COA / SDS

Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide

Discontinued Product

7712 has been discontinued. View all TrkB products.

Key Product Details

Description:	Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
Purity:	≥95% (HPLC)
Molecular Weight:	813.93

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Technical Data
Citations

Biological Activity for Semax

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) (4-10). It increases hippocampal BDNF and TrkB expression and levels in vivo. Semax regulates cortical nitric oxide (NO) and lipid peroxidation and is neuroprotective in a rat model of global ischemia. Semax sequesters copper ions and interacts directly with Aβ:Cu²⁺ oligomers leading to reduced amyloid β protein (Aβ) aggregation and fibrillogenesis. Semax increases viability of d-SH-SY5Y cells pre-incubated with Aβ_1-42 oligomers.

Technical Data for Semax

M. Wt	813.93
Formula	C₃₇H₅₁N₉O₁₀S
Single Letter Sequence	MEHFPGP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	80714-61-0
PubChem ID	9811102
InChi Key	AFEHBIGDWIGTEH-AQRCPPRCSA-N
Smiles	O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(NCC(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Semax

References are publications that support the biological activity of the product.

Dolotov Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006 PMID: 16996037
Sciacca Semax, a synthetic regulatory peptide, affects copper-induced Abeta aggregation and amyloid formation in artificial membrane models. ACS Chem.Neurosci. 2022 PMID: 35080861
Bashkatova Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain Res. 2001 PMID: 11245825

Semax

Tocris Bioscience, part of Bio-Techne | Catalog # 7712

Key Product Details

Biological Activity for Semax

Technical Data for Semax

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Semax

Product Documents for Semax

COA

Certificate of Analysis

SDS

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